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Is Your Heartburn Medication a Health Risk?

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Chronic heartburn is not fun; either is choosing what to take for it. There are antacids, foaming agents, H2 blockers, prokinetics, Bismuth subsalicylate products and proton pump inhibitors (PPIs) … and then you have to consider the potential side effects of each. They are FDA approved, so that must mean they are safe – right? Let’s take a look at some potential health risks related to heartburn medication.

The use of PPIs for heartburn has skyrocketed in recent years. Only now are we learning of the widespread misuse and potential adverse effects related to their long-term use. Considering that over 100 million PPI prescriptions are filled in the United States – totaling more than $14 billion – each year, I feel it is important for everyone to be educated about this best-selling class of drugs. They include prescription and over-the-counter products like Aciphex, Nexium, Prevacid and Prilosec.

Let’s get started by looking at the potential health risks of excessive heartburn medication use, and then move on to some natural ways to promote healthy digestion.

A Closer Look at Heartburn Medication and PPIs

Since the introduction of these powerful stomach acid suppressors over 25 years ago, PPIs have generally been perceived as safe. And the FDA did approve them for short-term use. Yet many individuals are not using them as intended.

More and more people are chronically taking PPIs for persistent conditions for years, which is bringing the long-term potential adverse effects under the spotlight. Be aware of the potential risks, including those related to kidney health, bone health, dementia, heart attacks and increased infection rates!

Dr. Ziyad Al-Aly, Assistant Professor of Medicine at Washington University School of Medicine, Co-Director at Clinical Epidemiology Center and Associate Chief of Staff for Research and Education at Veterans Affairs Saint Louis Health Care System, explains it well:

I think people see heartburn medication at the drug store and assume they’re completely safe. But there’s growing evidence they’re not as safe as we’ve thought. (Source)

Kidney Health Risk

CBS News reported in April 2016 the results of a study published in the Journal of the American Society of Nephrology that indicate “long-term use of a common type of medication used to treat heartburn, acid reflux and ulcers may lead to an increased risk of kidney disease and kidney failure.” This affirms prior research into PPIs that this group of drugs is associated with kidney damage.

According to the new data, “The risk of a decline in kidney function was 32 percent higher for people taking PPIs, and the risk of new cases of chronic kidney disease was 28 percent higher. Patients taking PPIs were 96 percent more likely to experience end-stage renal disease – kidney failure – than those who took H2 blockers.” These risks increased for about two years of use and then leveled out. (Source)

Bone Health Risk

The U.S. Food and Drug Administration has determined that “bone fractures are considered a safety concern when people use PPIs for a year or more,” or in high doses. These fractures seem to be concentrated on the hip, wrist and spine. Many researchers point to the decreased intestinal absorption of calcium as the culprit.

The administration has also published a drug safety warning that nutrient absorption, such as that of magnesium, calcium, iron and vitamin B12, may be affected by long-term PPI use. Low levels of calcium and magnesium can lead to health issues like osteoporosis and high blood pressure.

Dementia Risk

A report published in JAMA Neurology in February 2016 suggests there is an association between PPIs and risk of dementia in older patients. They have been shown “to be potentially involved in cognitive decline.” Findings point to some PPIs crossing the blood-brain barrier and interacting with brain enzymes.

This potential dementia risk may also be associated with the nutrient absorption effect of PPIs, since vitamin B12 deficiency has been shown to have an association with cognitive decline. The results of this study are similar to findings from a different study. More clinical trials are continuing.

Heart Attack Risk

Researchers at the Stanford University School of Medicine found an increased risk of heart attack in people who used PPIs, according to a June 2015 study. The results indicate “that PPI use was associated with a roughly 20 percent increase in the rate of subsequent heart-attack risk among all adult PPI users, even when excluding those also taking clopidogrel.”

While it doesn’t prove causation, it has raised serious concerns.

Increased Infection Risk

As PPIs block the production of stomach acid, it inhibits the acid’s function as a barrier against ingested pathogens. This leaves people more vulnerable to infections.

The FDA communicated an association between a digestive system infection named Clostridium difficile and PPIs in a warning. They have been linked to an increased risk of pneumonia and salmonella as well. (Source)

The aforementioned associations were made retrospectively, not prospectively, so no cause-and-effect relationships to these health issues have been studied. However, the risks are certainly worth considering!

What is the takeaway from all of this research? I would say that it is evidence that individuals who don’t need heartburn medication shouldn’t take it. If PPIs are medically necessary, it is best to use the lowest dose for the shortest duration. And, if you’ve been on a PPI for a long period of time, discuss the risks and benefits with your healthcare practitioner.

A Natural Health Perspective

There are a number of lifestyle changes you can try to ease heartburn symptoms. It helps to start with the contributing factors. suggests these causes that you may not have considered:

  • Smoking
  • Higher BMI or being overweight
  • NSAIDs and prescription drugs
  • Genetic factors
  • Certain foods, such as peppermint, ice cream, chocolate and others
  • Stress

Obviously, you can’t change your genes, but many people find relief by working on what they can affect. Other lifestyle-related things I would suggest are to avoid high-fat foods, stop eating a couple of hours before going to bed, eat smaller meals, and taking note of times when you have heartburn and try avoiding the foods eaten prior to that. Alcohol consumption may also be a factor as beer and wine, especially, may increase gastric acid secretions. (Source)

You may also want to consider a dietary supplement that supports healthy digestion.

Natural Supplement Alternatives



Advanced Heartburn Rescue by Terry Naturally



Gastric Repair Complex by Nutra BioGenesis



GastroVen by Premier Research Labs



Betaine HCl by Integrative Therapeutics



Acid Soothe by Enzymedica


Have you had success with a natural option for heartburn or negative effects from a heartburn medication? Please comment about it below so all of our readers can benefit!

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One Response to Is Your Heartburn Medication a Health Risk?

  1. Art Low May 22, 2016 at 2:49 pm #

    Theresa thank you, very informative on the affected by long-term PPI. Especially about B12. I just had and issue personally with that, where I had too much B12. But to your question:

    Acid Soothe by Enzymedica is my go to natural option for heartburn. I used to have issues with almost anything I ate… changed my diet and then the stuff that was “natural” came back to haunt me. Peanut Butter the worst and many raw foods for me. I started out with Enzymedica’s Digest Gold before each meal. That helped but still need more for the acid/heartburn issues I had since I was a teen. While their kids chewed gum I was gnawing some antacid chewable. Yes, even with digest enzyme I need something to soothe the pain I was dealing with and the pain was harsh! Oh bloating!!! That’s when I try their Acid Soothe, it took care of bloating asap! After that, I would take it with every meal. Then I noticed a funny thing, after using Acid Soothe and Digest Gold for a while I find, I did not NEED to take the Acid Soothe. I can skip a few meals and or go a week or two and not need it. Not sure what that means, One that is for sure at least for me anyway, the I am happy with the products and they have given me a rest on the symptom. And I can eat pizza again… Okay, maybe being able to eat pizza again is not a good thing, but every now and again everyone wants pizza again.

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