Berberine has several amazing benefits but someone recently asked me, what are the side effects of Berberine? I wasn’t familiar with many so I did some research to find out if there were any.
These are the Potential Side Effects of Berberine:
One article I found from The Examiner lists things to know about Berberine, including side effects of berberine:
- Berberine is able to activate an enzyme called AMPK (Adenosine Monophosphate-Activated Protein Kinase)
- Due to AMPK inhibition, berberine is normoglycemic (reduces blood sugar only if elevated). However, the reduction in blood sugar from berberine may make other hypoglycemics more likely to cause reduced blood sugar.
- High doses of berberine taken acutely, due to their poor intestinal uptake rate, may cause cramping and diarhhea; for this reason, berberine should be taken in multiple doses throughout the day.
- Berberine is known to inhibit CYP2D6 and CYP3A4 (an enzyme responsible for metabolism of toxins, drugs, carcinogens, etc.)
Berberine is one of the few supplements in the Examine.com database with human evidence that establishes it to be as effective as pharmaceuticals.”
Now that’s interesting to me since unfortunately, there aren’t many sources that would state a supplement is as effective as pharmaceuticals. It also seems to me that due to AMPK suppression, the article is suggesting that berberine may help reduce blood sugar if it is elevated, but would not, if it isn’t. So for someone with elevated blood sugar, the article suggests berberine would not have side effects and in fact, might function more like adaptogens do. If you are unfamiliar with adaptogens, they are herbs (usually) that work with the body to increase or decrease the bodies ability to adapt to a specific situation. In that case, it might actually be better than a drug since it doesn’t have side effects.
However, it does go on to state that due to the increase in AMPK, berberine will have muscle-suppressing effects. Not to worry though, this can be reversed by intense workouts and activities like weight-lifting and strength-training exercises such as push-ups.
Probably the most important side effects of berberine to note (in my opinion) is that it inhibits the enzyme CYP3A4, a member of the Cytochrome P450 family. What that means is that berberine may decrease how fast the liver breaks down medications. Those medications then could have a longer life and potentially have a stronger effect than intended. Avoiding berberine while on medication is similar to avoiding grapefruit juice when you’re on certain medications. Grapefruit juice has an enzyme that prevents drugs from breaking down in the body as quickly as intended, same as berberine.
What should the Berberine dosage be?
A general guideline would be that the dose is based on the actual berberine content, standardized is best. Berberine dosing could be from 500 mg -2,000 mg a day, in divided doses. Smaller, divided doses are best to avoid stomach upset, cramping, and diarrhea.
Berberine should be taken with a meal to be absorbed most effectively (due to the glucose and lipid release during eating).
Read about the Amazing Health Benefits of Berberine to see if berberine may benefit you. Then, give berberine a try as a natural anti-microbial, to support healthy blood sugar levels, support heart health and provide super immune support. Buy some of the best brands of berberine supplements now.
If you have used berberine supplements, share you story below. There are many who are looking for alternatives to diabetes medication and would like to know if this works or doesn’t!
Other Articles You Might Find Interesting:
Efficacy of Berberine in Patients with Type 2 Diabetes – This pilot study demonstrated that, “In the regulation of lipid metabolism, berberine activity is better than metformin. By week 13, triglycerides and total cholesterol in the berberine group had decreased and were significantly lower than in the metformin group. Liver and kidney functions were monitored in this study for side effects of berberine. No significant changes of plasma ALT, γ-GT and creatinine were observed during the 13 weeks of berberine treatment (Table 3). None of the patients were observed with pronounced (more than 50%) elevation in liver enzymes or creatinine.”
Berberine, a Natural Plant Product, Activates AMP-Activated Protein Kinase With Beneficial Metabolic Effects in Diabetic and Insulin-Resistant States – “These findings suggest that berberine displays beneficial effects in the treatment of diabetes and obesity at least in part via stimulation of AMPK activity.”
A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndrome – “Intake of Berberine improved some of the metabolic and hormonal derangements in a group of treated Chinese women with PCOS. “